Structure and function of major histocompatibility complex class I antigens
نویسندگان
چکیده
منابع مشابه
Frequency of Major Histocompatibility Antigens Class I in Mazandaran Province
Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran. Materials and methods: In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center af...
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INTRODUCTION ..................................................................................... 254 Class 1 MHC Polypeptides ...................................................................... 256 THE STRUCTURE OF HLA-A2 .................................................................. 257 Structural Overview .............................................................................. ...
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Description The genes of the Human Leukocyte Antigen (HLA) system reside on chromosome 6, and code for cellsurface proteins that play a crucial role in the presentation of endogenic peptides to effector cells of the immune system. The HLA Class I protein molecule is a heterodimer, made up of two chains; a heavy one and a light one (beta 2 microglobulin). The HLA-B gene is one of the three HLA C...
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Recent studies have shown that the H-2K and H-2D transplantation antigens are expressed differentially in different tissues of mouse. Our previous investigations also established that in thioglycolate-stimulated peritoneal macrophages the H-2Dk antigen exists in distinct cell surface and intracellular forms. These two forms are glycosylated differently. In this report, we have found that (1) H-...
متن کاملMajor histocompatibility complex class I antigens and the control of viral infections by natural killer cells.
Natural killer (NK) cells are large, granular cytotoxic lymphocytes which represent a major portion of the lymphocyte infiltrate of infected tissue at early stages of viral infections (35, 37). NK cells become cytolytically activated and proliferate in vivo after exposure either to alpha, beta, or gamma interferon (IFN-a, -b or -g) or interleukin-2 (4, 6–8, 50). The peak in NK cell activation a...
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ژورنال
عنوان ژورنال: Current Opinion in Organ Transplantation
سال: 2010
ISSN: 1087-2418
DOI: 10.1097/mot.0b013e32833bfb33